R 40244
Fluorochloridone
CAS: 61213-25-0
Molecular Formula: C12H10Cl2F3NO
R 40244 - Names and Identifiers
R 40244 - Physico-chemical Properties
| Molecular Formula | C12H10Cl2F3NO |
| Molar Mass | 312.12 |
| Density | 1.3924 (estimate) |
| Melting Point | 67.65°C |
| Boling Point | 212.5 °C |
| Flash Point | >100°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 2.02E-08mmHg at 25°C |
| Appearance | Solid |
| Color | Pale Brown to Light Brown |
| pKa | -3.59±0.60(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Refractive Index | 1.536 |
| Physical and Chemical Properties | The drug was a brown solid. m. P. 42-73 °c, vapor pressure 8 x 102Pa (25 °c). Soluble in acetone, chlorobenzene, ethanol, xylene and other organic solvents, solubility of 100 ~ 150g/L. Solubility in kerosene <5g/L. Solubility in water 28mg/L. Partition coefficient (N-octanol/water) 2300(20 °c). 60 C, pH value of 4 when the half aging period is 7d,60 C, pH value of 7 for 18d, soil half-life 11 ~ 100d. |
| Use | Used for pre-treatment of winter wheat, rye, cotton, potato and other crops, to control broad-leaved weeds |
R 40244 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27 - Take off immediately all contaminated clothing. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| RTECS | UY5746500 |
R 40244 - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| toxicity | Acute Oral LD504000mg/kg in male rats, acute percutaneous LD50>5000mg/kg in rabbits, rats were acutely inhaled LC5010.3mg/L (4H). Slightly irritating to the skin and eyes of rabbits. Male rats 2 years feeding Test No effect dose of 100mg/kg feed (3.9mg/kg per day), female rats 2 years feeding Test No effect dose of 400mg/kg feed (19.3mg/kg per day). Ames test and mouse lymphoid tissue test showed no mutagenicity. Rainbow trout LC504mg/L(96H), blue gill fish LC505mg/L(96H). Quail LD50>2150mg/kg. Bee LD50<0.1mg/only. |
| Application | fluroxolone is a pyrrolidone herbicide, which is an inhibitor of carotene synthesis, can be used to control winter wheat and winter rye in the field, Ivy Leaf, Borna and Viola, cotton field, reverse branch amaranth, Portulaca oleracea and Solanum nigrum, potato field of swine, Solanum nigrum and Persia, with 500 ~ 700g active ingredient/hm2 pre-bud application, broad-leaved weeds were controlled. Carrot grown in light soil, with 500g active ingredient/hm2 application, and can increase production. |
| production method | preparation method 1-trifluoromethylaniline is acylated with dichloroacetyl chloride and then reacted with 3-bromopropene, the resultant was reacted at 125 ° C. For 17h in the presence of butyltriphenylphosphonium chloride to obtain fluralone. N-allyl-m-trifluoromethyl aniline is synthesized by adding 0.1mol of M-trifluoromethyl aniline, 0.1mol of triethylamine, 50ml of toluene and appropriate amount of catalyst to heat up to 60 ℃, Dropwise adding 0.1mol of allyl chloride, dropwise rising temperature to 85 ℃, reaction for several hours, reaction liquid washing, drying, desolvation and unreacted M-trifluoromethyl aniline, product 11.5g, content 93.4%, yield 76.8%. Synthesis of N-allyl-N-m-trifluoromethylphenyl-2, 2-dichloroacetamide 0.05mol of triethylamine, 0.05mol of N-allyl-m-trifluoromethylaniline and 40ml of dichloromethane were added to the flask, and 0.06mol of dichloroacetyl chloride was added dropwise. After dropping, warming up to 60 ℃, keeping the reaction for 1H, washing with water, drying and dissolving, the product was 16.6g, the content was 88.8%, and the yield was 94.5%. Synthesis of Fluridone 10g of N-allyl N-m-trifluoromethylphenyl-2, 2-dichloroacetamide, solvent and catalyst were added to the flask and heated to reflux. After completion of the reaction, the reaction mixture was neutralized with dilute acid, separated into layers, dried, and desolvated under reduced pressure to obtain 6.8g of Fluridone. |
Last Update：2024-04-10 22:29:15
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